EDITORIAL | |
1. | New developments in AKD, numbers, Scopus, Thomson Gale and CONSORT Bilgin Timuralp Page 307 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
2. | Coronary angioplasty induced oxidative stress and its relation with metoprolol use and plasma homocysteine levels Dilek Çiçek, Lülüfer Tamer, Hasan Pekdemir, V.Gökhan Cin, Hatice Yıldırım, Asuhan Aksoy Kara, Mustafa Yurtdaş PMID: 17162274 Pages 308 - 313 Objective: Short episodes of myocardial ischemia during coronary angioplasty may induce oxidative stress and increase lipid peroxida- tion. The aim of this study was to determine the effect of metoprolol on lipid peroxidation by measurements of malondialdehyde (MDA) and total antioxidant capacity (TRAP) in patients undergoing angioplasty. The relations between homocysteine level and lipid peroxida- tion were also studied. Methods: Forty-six patients (mean age 57 years, 37 males) undergoing elective angioplasty were enrolled. Metoprolol treatment was ini- tiated in 27 patients (group 1), meanwhile 19 patients could not take metoprolol due to diverse contraindications (group 2). Results: Following angioplasty, while venous MDA levels decreased in group 1 (0.188±0.021 vs. 0.159±0.020 nmol/ml, p=0.05), an increase was detected in group 2 (0.203±0.025 vs. 0.229±0.024 nmol/ml, p=0.045) as compared with baseline levels. In group 1, TRAP levels marked- ly increased after angioplasty in venous samples (1.201±0.036 vs. 1.478±0.044 mmol/L, p=0.0001). However, small increase was observed for TRAP in group 2 (1.274±0.043 vs. 1.363±0.053 mmol/L, p=0.05). There was no significant change in plasma homocysteine levels with angioplasty. There was no significant correlation between homocysteine, changes in MDA and TRAP levels either. Conclusion: Administration of metoprolol may cause a reduction in the oxidative stress and an increase in the antioxidant activity in patients undergoing elective angioplasty. |
3. | Prevalence, incidence, predictors and outcome of type 2 diabetes in Turkey Altan Onat, Gülay Hergenç, Hüseyin Uyarel, Günay Can, Hakan Özhan PMID: 17162275 Pages 314 - 321 Objectives: To investigate prospectively the incidence, certain predictors and outcomes of type 2 diabetes (DM), as well as to determine its prevalence cross-sectionally, in a representative sample of Turkish men and women. Methods: Prospective evaluation of 3401 male and female participants (aged 48.2 ±12 years). Follow-up constituted 19,050 person-years. In- dividuals with DM were diagnosed with criteria of the American Diabetes Association. Fatal and nonfatal coronary heart disease (CHD) was identified by clinical findings and Minnesota coding of resting electrocardiograms. Cut-points of ≥95 cm in males and ≥91 cm in females we- re selected for abdominal obesity. For prospective evaluations, cases with DM or CHD were excluded. Results: Prevalence of DM in Turkish adults was estimated as 2.89 million (11.0% of the population aged ≥35 years). Over a mean follow-up of 5.9 years, incident DM developed in 223 subjects, yielding an incidence per 1000 person-years of 11.0 in women and 12.4 in men. This cor- responded to a 300,000 annual incidence. Following risk parameter levels but not HDL-cholesterol were significantly elevated at baseline in subjects developing DM compared to those without: age (5 years), waist girth (7 cm), blood pressure (12/6 mmHg), apolipoprotein B (7 mg/dl), total cholesterol (14 mg/dl), and fasting triglycerides (only in women, 52 mg/dl). Abdominal obesity (RR 2.61 [95%CI 1.87; 3.63]) and age in both genders, hypertension (RR 1.81 [95%CI 1.10; 2.98]) and low HDL-cholesterol in men alone were significant independent predictors of DM. Di- abetes mellitus was a significant and independent predictor of fatal and nonfatal CHD, with a RR of 1.81 (95%CI 1.19; 2.75), after adjustment for sex, age, hypertension, waist circumference, serum total cholesterol and smoking status. Conclusions: The annual incidence of DM in Turkey rises very rapidly, currently stands at 300,000, and, hence, its prevalence also rises cor- respondingly. Insulin resistance appears to be a weak determinant of DM in Turkish women while abdominal obesity is the main determi- nant. Multivariately adjusted DM is a significant independent predictor of fatal and nonfatal CHD. These observations emphasize that me- asures to reverse or stop the “epidemic” of abdominal obesity are severely required. |
4. | LOAD limits for ambulatory pulse pressure and double product in normotensive and hypertensive subjects Mustafa Cemri, Mert Ceyhan, Uğur Hodoğlugil, Deniz Barlas Durakoğlugil, Halis Dörtlemez, Hakan Zengil PMID: 17162276 Pages 322 - 326 Objective: The aim of this study was to to determine possible daytime (awake hours) and nighttime (sleeping hours) LOAD limits for am- bulatory pulse pressure (PP) and double product (DP) in hypertensive (HT) subjects and secondly to assess whether there were signifi- cant differences in the LOAD values between hypertensive (HT) and normotensive (NT) subjects. Methods: Seventy-eight untreated essential HT (46 female, 32 male; mean age 51.9±1.4 years) and 115 NT (89 female, 26 male; mean age 40.8±1.1 years) subjects participated in this study. Ambulatory blood pressure monitoring (ABPM) devices were applied to these subjects for 48 hours. Different possible ambulatory PP LOAD limits between 40 and 55 mmHg with 5 mmHg increments and ambulatory DP LOAD limits between 6000 and 12000 mmHg.beats/min with 1000 mmHg.beats/min increments were used. Then according to these limits, LOAD values of NT and HT subjects have been assessed for daytime, nighttime and 48 hours. Results: There were significant differences between NT and HT subjects in all the values for both ambulatory PP and DP. Although me- an (total, day and night mean) values of HT subjects were higher approximately by 20% than of NT subjects, LOAD values for ambulatory PP in HTs were 33%-415% higher than in NTs (p<0.001). Hypertensive subjects' mean (total, day and night mean) values of DP were by 23%-33% higher than NTs values, but LOAD values for ambulatory DP in hypertensives were approximately 43%-673% higher than in NT subjects (p<0.001). Conclusions: We showed that although there were significant differences in the 48- hour, daytime and nighttime PP and DP means bet- ween NT and HT subjects, these differences became more prominent when possible LOAD limits were used for ambulatory PP and DP, One of these possible ambulatory PP and DP LOAD limits can be used in the clinical settings if a relationship with the end-organ dama- ge will be showed by further studies. |
5. | Quality of life and functional status in congestive heart failure Hale Karapolat, Berrin Durmaz, Sanem Nalbantgil, İsa Durmaz PMID: 17162277 Pages 327 - 332 Objective: To assess health related quality of life of patients with congestive heart failure (CHF), to correlate quality of life with other func- tional parameters; maximal oxygen uptake (peak VO2) with submaximal tests (two minute walking test and shuttle walk test) and New York Heart Association (NYHA) with other clinical variables. Methods: We evaluated 35 stable congestive heart failure patients (NYHA II-III). Functional status was assessed by NYHA classification, maximal oxygen uptake (peak VO2) and submaximal tests (two minute walk test and shuttle walk test). Health related quality of life was measured with short form 36 health survey (SF 36). Results: NYHA functional class was correlated with social functioning of SF 36, peak VO2 and shuttle walk test. Peak VO2 was correlat- ed with most of the parameters of SF 36. On the other hand 2 minute walk test and shuttle walk test were correlated with social func- tioning of SF 36. There was a correlation between peak VO2 and submaximal test, but there was no correlation between left ventricular ejection fraction, peak VO2 and NYHA class. Conclusion: Social functioning is impaired in patients with congestive heart failure. There is a correlation between maximal and sub- maximal tests. The maximal and submaximal tests can explain some degree of quality of life. Functional status can be explained with peak VO2 and shuttle walk test apart from NYHA class. |
EDITORIAL COMMENT | |
6. | Determination of functional capacity in heart failure Çavlan Çiftçi PMID: 17162278 Pages 333 - 334 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
7. | Effects of gender and altitude on short-term heart rate variability in children Ainash A. Sharshenova, Elvira J. Majikova, Omor T. Kasimov, Gulmira Kudaiberdieva PMID: 17162279 Pages 335 - 339 Objective: We aimed to study short-term heart rate variability (HRV) in 113 apparently healthy children permanent residents of moderate alti- tudes, the effects of gender and altitude. Methods: Children were assigned into 3 groups according with altitude of residence: Group 1 - 1650 m/a/s/l (n=38), Group 2 - 1740 m/a/s/l (n=36) and Group 3 - 2030 m/a/s/l (n=39). All children underwent short-term electrocardiographic recordings with spectral analysis of HRV at rest and during standing. Statistical analysis was performed using multivariate ANOVA analysis. Results: Heart rate variability analysis showed significant increase in SDNN, high frequency and total powers in parallel with increase of the altitude of residence (p<0.0001, p<0.03 and p<0.01, respectively). The magnitude of the HRV response to posture did not differ between groups except index of sympathetic modulation, LFNU, which rose to a significantly lesser degree (F=3.45, p<0.03) in Group 3, as compared with Group 1 and 2. Girls had lower HRV as compared with boys. Conclusion: Thus, in apparently healthy children, residents of moderate altitudes, increase in altitude levels is accompanied by higher overall vari- ability and parasympathetic modulation of the sinus node and lower sympathetic response to posture. Heart rate variability in children, residents of moderate altitudes is also dependent of gender, resembling similar relationship in inhabitants of sea level. |
8. | Early-mid term results of the one and a half ventricle repair Ece Salihoğlu, Ersin Erek, Yusuf K. Yalçınbaş, Tayyar Sarıoğlu, Ayşe Sarıoğlu PMID: 17162280 Pages 340 - 344 Objective: The aim of this study is to investigate the early and mid term results of one and a half ventricle repair. Methods: Pathological and demographic data, prior palliative operations selection criteria and operative properties of six patients with right ventricular hypoplasia undergoing one and a half ventricle repair were investigated. Patients were followed for mean 55.6±18.9 months by clinical and echocardiographic examinations. Results: One patient died in the early-mid term follow-up period. The intensive care unit and hospitalization mean time were 2.8± 0.83 and 11.25± 6.55 days respectively. One patient had recurrent pleural effusion; she also had epicardial permanent pace implantation for atri- oventricular block within the postoperative second month. Another patient was reoperated for important tricuspid and pulmonic valve regurgitation at postoperative 3rd year. All other patients were followed with medical therapy in NYHA class I-II status. Conclusion: The early and mid-term results of one and a half ventricle repair seem to be acceptable. This method can be a good alterna- tive to Fontan repair in suitable patients. |
EDITORIAL COMMENT | |
9. | Fenestration and its effects on the end-organs İlker Alat PMID: 17162281 Pages 345 - 346 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
10. | Effects of different cardioplegic solutions on nitric oxide release from coronary vasculature in diabetic patients undergoing coronary artery bypass surgery Pelin Karaca, Nurgül Yurtseven, Yavuz Enç, Tamer Aksoy, Onur Sokullu, Fuat Bilgen, Sevim Canik PMID: 17162282 Pages 347 - 351 Objective: The aim of this study was to compare the effects of two different cardioplegic solutions on nitric oxide (NO) release from coro- nary vasculature in patients with type II diabetes mellitus undergoing coronary artery bypass grafting (CABG) surgery. Methods: Forty patients undergoing elective CABG surgery were randomized to be given crystalloid (Group 1 ) or blood (Group 2) cardiople- gia. Aortic and coronary sinus blood samples were taken at three different time periods and the release of NO from the coronary vascula- ture was determined by measuring its stable end-products, nitrite and nitrate. The difference between the aortic and coronary sinus con- centrations of nitrite and nitrate represents the amount of NO released by coronary vascular bed. Results: Before application of aortic cross-clamp, at T1 period, the levels of nitrite/nitrate from the coronary vasculature were similar in both groups (6.53±1.21 μM vs 6.07±1.24 μM, p> 0.05). However after the removal of cross-clamp, a significant decrease in NO was observed in Group 1 as compared with Group 2 (4.21±0.73 μM vs 4.92±1.02 μM, p< 0.01). This decrease persisted at T3 period, after 30 minutes of reper- fusion in group 1 being significantly different from group 2 (3.86±0.49 vs 4.37±0.72 μM, p<0.05). Conclusion: This study has shown that in patients with type II diabetes mellitus crystalloid cardioplegia causes a decrease in the release of NO from coronary vascular bed during aortic cross-clamp and reperfusion period whereas more physiologic blood cardioplegia did not. Our findingsindicatethatbloodcardioplegiaprotectsendothelialfunctionbetterthancrystalloidcardioplegiaindiabeticpatients. |
EDITORIAL COMMENT | |
11. | Cardioplegic solutions and nitric oxide in coronary artery bypass surgery Rıza Türköz PMID: 17162283 Page 352 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
12. | Relationship between coronary risk calculation and distribution of the coronary artery lesions and risk factors Cemal Sağ, Mustafa Özkan, Mehmet Uzun, Mehmet Yokuşoğlu, Oben Baysan, Kürşad Erinç, Ersoy Işık PMID: 17162284 Pages 353 - 357 Objectives: Early diagnosis and treatment of coronary artery disease is gaining more importance because of its increasing incidence. The calculation of coronary risk score is one of the most important approaches. The aim of the study is to find out the relation between coro- nary risk score and vessel distribution of the coronary heart disease. Methods: The study included 49 patients (mean age= 63±8 years; 36 males) whose coronary disease was proven by coronary angiogra- phy. The severity of the disease is established according to the number of the vessels with >50% stenosis. Results: According to the results; age (p=0.548), gender (p=0.116), uric acid (p=0.091), and smoking (p=0.718) are not effective on diseased vessel distribution. Similarly, total coronary risk score and vessel involvement was not correlated (p=0.115). The ten year coronary risk and vessel involvement was not in good correlation, too (p=0.523). Low-density lipoprotein (LDL)-cholesterol levels were lower in patients with multiple vessel disease but the statistical significance was borderline (p=0.051). High-density lipoprotein (HDL)-cholesterol levels were lower in multiple vessel disease (p=0.004). Both LDL-cholesterol and HDL-cholesterol scores were decreasing with increased num- ber of involved vessels (p=0.035, p=0.001). Multivariate analysis revealed that blood pressure score, and HDL cholesterol score were directly related and LDL-score were inversely related to the number of the involved vessels. The height and vessel involvement was also in good correlation (p=0.024). Conclusion: The LDL-cholesterol, HDL-cholesterol, diastolic blood pressure and height are affective on the number of the involved ves- sels. The total coronary risk scores are not correlated with the severity and distribution of the disease. |
REVIEW | |
13. | How useful are β-blockers in cardiovascular disease? Sripal Bangalore, Sanobar Parkar, Franz H. Messerli PMID: 17162285 Pages 358 - 363 Recent studies have shown that β-blockers in patients with hypertension is associated with an increased risk of cardiovascular events, in particular stroke, leading to headlines speculating the end of theβ-blocker era. The objective of this review is to critically examine the use- fulness of β-blockers in cardiovascular diseases. We reviewed the currently available evidence for the usefulness of β-blockers in pati- ents with hypertension and also assessed the efficacy of its use for other indications, like, chronic heart failure, stable angina, myocardi- al infarction, arrhythmias etc. The review of the currently available literature shows that for patients with uncomplicated hypertension, the- re is paucity of data or absence of evidence to support use of β-blockers as monotherapy or as first line agent. Given the risk of stroke and numerous unacceptable adverse effects, the risk benefit ratio for β-blockers is not acceptable for this indication. However, β-bloc- kers are very efficacious agents for the treatment of heart failure, certain types of arrhythmia, and post myocardial infarction. The various guideline committees should seriously reconsider their decision about their endorsement of β-blockers as first line therapy for uncompli- cated hypertension. However, this is applicable for hypertension and β-blockers continue to be efficacious for other indications. |
14. | Nitric oxide and cardiovascular system Atiye Çengel PMID: 17162286 Pages 364 - 368 Endothelium has many important functions including the control of blood-tissue permeability and vascular tonus, regulation of vascular sur- face properties for homeostasis and inflammation. Nitric oxide is the chief molecule in regulation of endothelial functions. Nitric oxide de- ficiency, which is also known as endothelial dysfunction, is the first step for the occurrence of many disease states in cardiovascular sys- tem including heart failure, hypertension, dyslipidemia, insulin resistance, diabetes mellitus, hyperhomocysteinemia and smoking. This re- view deals with the importance of nitric oxide for cardiovascular system. It also includes the latest improvements in the diagnosis and tre- atment of endothelial dysfunction. |
SCIENTIFIC LETTER | |
15. | Composite graft in cases of insufficient length of internal thoracic artery Ufuk Tütün, Ferit Çiçekçioğlu, Ayşen Aksöyek, Ali İhsan Parlar, Ahmet Tulga Ulus, Salih Fehmi Katırcıoğlu PMID: 17162287 Pages 369 - 371 Abstract |Full Text PDF |
16. | Surgical treatment of isolated cardiac echinococcosis,located in the right ventricular outflow tract Bülent Meşe, Feragat Uygur, Mustafa B. Erdoğan, Rıza Asil, Birol Yamak PMID: 17162288 Pages 372 - 373 Abstract |Full Text PDF |
CASE REPORT | |
17. | Muscular bridge causing non- ST-segment elevation myocardial infarction Pelin Aytan, Gülay Ulusal, Ezgi Coşkun Yenigün, Özgür Yıldırım, Atakan Pırpır, Safa Yıldırım PMID: 17162289 Pages 374 - 375 Abstract |Full Text PDF |
EDITORIAL COMMENT | |
18. | Myocardial bridging: a rare speciality without clinical significance? Ali Erdoğan, Harald Greiss PMID: 17162290 Page 376 Abstract |Full Text PDF |
CASE REPORT | |
19. | Coronary rupture to the right ventricle during PTCA for myocardial bridge Ergun Demirsoy, Harun Arbatlı, Mehmet Ünal, Naci Yağan, Oğuz Yılmaz, Faruk Tükenmez, Deniz Şener, Bingür Sönmez PMID: 17162291 Pages 377 - 379 Abstract |Full Text PDF |
20. | Spinal epidural hematoma associated with streptokinase therapy Nermin Çakıcı, Nihal Akar, Kürşad Öneç, Sinan Aydoğdu, Erdem Diker PMID: 17162292 Pages 380 - 382 Abstract |Full Text PDF |
21. | An uncommon congenital anomaly of coronary arteries misdiagnosed as intracoronary thrombus: woven coronary artery disease Dayimi Kaya, Celal Kilit, Ersel Onrat PMID: 17162293 Pages 383 - 384 Abstract |Full Text PDF |
22. | Exercise-induced coronary artery dissection treated with an anticoagulant and antiaggregants Sabahattin Umman, Ayhan Olcay, Murat Sezer, Do¤an Erdoğan PMID: 17162294 Pages 385 - 386 Abstract |Full Text PDF |
23. | Asymptomatic congenital pericardial defect: an aspect of diagnostic modalities and treatment Cem Barçın, Ayhan Olcay, Murat Kocaoğlu, Kaan Ataç, Hürkan Kurşaklıoğlu PMID: 17162295 Pages 387 - 389 Abstract |Full Text PDF |
LETTER TO THE EDITOR | |
24. | G-CSF in acute myocardial infarction - Experimental and clinical findings/ G-CSF in acute myocardial infarction: a word of caution Ahmet Rüçhan Akar, Serkan Durdu, Pervin Topçuoğlu PMID: 17162296 Pages 390 - 391 Abstract |Full Text PDF |
25. | How could sudden cardiac deaths on the athletic fields be prevented? Erdem Kaşıkçıoğlu PMID: 17162297 Pages 392 - 393 Abstract |Full Text PDF |
26. | Falls and myocardial infarction in diabetic elderly İhsan Üstün, Levent Özçakar, Nilgün Üstün, Tuncay Delibaşı PMID: 17162298 Page 394 Abstract |Full Text PDF |
27. | Cut-off values of BNP and NT-BNP for diagnosis of heart failure in emergency service Onur Akpınar, Mehmet Kanadaşı, T.Fikret İlgenli PMID: 17162299 Pages 395 - 396 Abstract |Full Text PDF |
28. | Pentalogy of Fallot in a patient with Down syndrome Emine Dibek Mısırlıoğlu, Didem Aliefendioğlu, Mehmet Tolga Doğru, Cihat Şanlı PMID: 17162300 Page 397 Abstract |Full Text PDF |
E-PAGE ORIGINAL IMAGES | |
29. | Bilateral subclavian vein thrombosis and vena cava superior syndrome with Behcet’s disease Muzaffer Bahçivan, Semih Yücel PMID: 17162301 Page 398 Abstract |Full Text PDF |
30. | Pulmonary embolism during echocardiography: thrombus in transit Hakan Özhan, Ahmet Kaya, Mehmet Yazıcı, Sinan Albayrak, Enver Erbilen, Serkan Bulur PMID: 17162302 Pages 399 - 400 Abstract |Full Text PDF |
31. | Infective endocarditis involving the pulmonary valve in a patient with malignant melanoma Bahri Akdeniz, Özer Badak, Nezihi Barış PMID: 17162303 Pages 401 - 402 Abstract |Full Text PDF |
32. | An unusual form of double outlet right ventricle Mehmet Yokuşoğlu, Ali Cevat Tanalp, Mehmet Uzun, Nail Bulakbaşı, Ersoy Işık PMID: 17162304 Pages 403 - 404 Abstract |Full Text PDF |
33. | Incidental diagnosis of Scimitar syndrome using 3-D chest computed tomography in a child Ömer Faruk Doğan, Burak E. Onuk, Metin Demircin PMID: 17162305 Pages 405 - 406 Abstract |Full Text PDF |
34. | Left ventricular mass Mehmet Yokuşoğlu, Mehmet Uzun, Cem Köz, Nail Bulakbaşı PMID: 17162306 Page 407 Abstract |Full Text PDF |
35. | Incidental diagnosis of membranous obstruction of the inferior vena cava using echocardiography in an asymptomatic child Dursun Alehan, Ömer Faruk Doğan PMID: 17162307 Page 408 Abstract |Full Text PDF |
36. | Ascending aorta aneurysm and type A dissection in association with aortic coarctation Muzaffer Elmalı, Muzaffer Bahçivan, Mehmet Selim Nural PMID: 17162308 Pages 409 - 410 Abstract |Full Text PDF |
37. | Report of a case with huge Osborn waves Yeşim Hoşcan, Mustafa Özgül PMID: 17162309 Pages 411 - 412 Abstract |Full Text PDF |
MISCELLANEOUS | |
38. | Dr. Nanda Honored with the Ellis Island Medal of Honor Page 413 Abstract |Full Text PDF |
39. | Gladstone ranks No. 1 Page 414 Abstract |Full Text PDF |
AUTHOR INDEX | |
40. | Author Index Pages 415 - 418 Abstract |Full Text PDF |
SUBJECT INDEX | |
41. | Subject Index Pages 419 - 422 Abstract |Full Text PDF |
REFEREE INDEX | |
42. | Referee Index Pages 423 - 424 Abstract |Full Text PDF |
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