ISSN 2149-2263 | E-ISSN 2149-2271
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Relationship between no-reflow phenomenon and serotonin levels in patients with acute ST-elevation myocardial infarction who underwent primary percutaneous intervention [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(3): 253-259 | DOI: 10.5152/akd.2010.066

Relationship between no-reflow phenomenon and serotonin levels in patients with acute ST-elevation myocardial infarction who underwent primary percutaneous intervention

Ramazan Topsakal1, Mehmet G. Kaya1, Ekrem Karakaya3, Özgür Günebakmaz3, Ali Doğan1, M. Tuğrul İnanç1, Bahadır Şarlı1, İbrahim Özdoğru7, Ali Ergin1
1Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey
2Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey
3Clinic of Cardiology, Dünya Hospital, Kayseri-Turkey
4Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey
5Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey
6Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey
7Department of Cardiology, Medical Faculty, Erciyes University, Kayseri
8Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey

Objective: Our aim was to investigate the effects of serotonin, which is a severe vasoconstrictor agent, on the occurrence of no-reflow phenomenon. Methods: In this cross-sectional controlled study, 40 patients, admitted to our clinic with chest pain in the first 12 hours and underwent primary percutaneous coronary intervention because of acute myocardial infarction were enrolled. Patients with TIMI 0 grade basal flow and normal post-procedure flow were included in group 1 and patients with flow grade TIMI ≤were enrolled in group 2. To measure the serotonin levels, blood samples were collected from the coronary ostium before the procedure. Results: In group 1, there were 25 patients (20 males, 5 females) and the mean age was 58±11 years; in group 2 there were 15 patients (13 males, 2 females) and the mean age was 62±8 years. The mean serotonin level in platelet in group 1 was 476±208 ng/109 platelet and in group 2-542±273 ng/109 platelet. The difference was not statistically significant (p=0.39). When we compared the serum serotonin levels, it was 41.4±40.8 ng/ml for group 1, but 66.7±45.7 ng/ml for group 2. Although the serum serotonin levels were higher in group 2, the difference was not statistically significant (p=0.07). Conclusion: There was no effect of serotonin level in the development of no-reflow, in patients to whom primary coronary percutaneous intervention was applied.

Keywords: No-reflow phenomenon, serotonin, vasoconstriction, myocardial infarction

Ramazan Topsakal, Mehmet G. Kaya, Ekrem Karakaya, Özgür Günebakmaz, Ali Doğan, M. Tuğrul İnanç, Bahadır Şarlı, İbrahim Özdoğru, Ali Ergin. Relationship between no-reflow phenomenon and serotonin levels in patients with acute ST-elevation myocardial infarction who underwent primary percutaneous intervention. Anatol J Cardiol. 2010; 10(3): 253-259
Manuscript Language: English


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