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The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(3): 175-182 | DOI: 10.5152/akd.2015.6010  

The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender

Derya Beyza Sayın Kocakap1, Mehmet Tolga Doğru2, Vedat Şimşek2, Feryal Çabuk1, Nesligül Yıldırım2, Yunus Çelik2, Sibel Alyılmaz Bekmez1, Solmaz Erdem3
1Departments of Medical Genetics, Faculty of Medicine, Kırıkkale University; Kırıkkale- Turkey
2Cardiology, Faculty of Medicine, Kırıkkale University; Kırıkkale- Turkey
3Medical Biology, Faculty of Medicine, Kırıkkale University; Kırıkkale- Turkey

Objective: Coronary artery disease (CAD) is a common, complex, and progressive disorder characterized by the accumulation of lipids and fibrous elements in the arteries. It is one of the leading causes of death in industrialized nations. Oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays an important role in the initiation and progression of atherosclerosis. Paraoxonase1 (PON1) is involved in lipid metabolism and is believed to protect LDL oxidation. In our study, we aimed to clarify the relationship between PON1 gene L55M polymorphism and the extent and severity of CAD.
Methods: In total, 114 patients (54 males, mean age: 56.7±12.0 years; 60 females, mean age: 55.7±13.2 years) with stable angina or angina equivalent symptoms were enrolled in this prospective study. Cardiological evaluation was performed with electrocardiogram and transthoracic echocardiogram. The presence of hypertension, dyslipidemia, diabetes, and smoking status were ascertained. The patients were grouped according to their Gensini scores and gender. Genetic analysis of the PON1 gene L55M polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism.
Results: We determined that the LL genotype was more prevalent in patients with Gensini score higher than or equal to 20 (p=0.026) and that this correlated with severe atherosclerotic coronary artery lesions in both gender groups, reaching a statistical significance in the female subjects (p=0.038).
Conclusion: It was thought that the PON1 gene L55M polymorphism plays a significant role in CAD progression, especially in females. (Anatol J Cardiol 2016; 16: 175-82)

Keywords: paraoxonase1, coronary artery disease, atherosclerosis, L55M polymorphism


Derya Beyza Sayın Kocakap, Mehmet Tolga Doğru, Vedat Şimşek, Feryal Çabuk, Nesligül Yıldırım, Yunus Çelik, Sibel Alyılmaz Bekmez, Solmaz Erdem. The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender. Anatol J Cardiol. 2016; 16(3): 175-182

Corresponding Author: Derya Beyza Sayın Kocakap, Türkiye


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