ISSN 2149-2263 | E-ISSN 2149-2271
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Non-alcoholic fatty liver disease–From the cardiologist perspective [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(7): 534-541 | DOI: 10.14744/AnatolJCardiol.2016.7049

Non-alcoholic fatty liver disease–From the cardiologist perspective

Oana Sîrbu1, Mariana Floria2, Petru Dascalita1, Victorita Şorodoc2, Laurentiu Şorodoc2
1Gr. T. Popa University of Medicine and Pharmacy, Iaşi-România
2Gr. T. Popa University of Medicine and Pharmacy and 2Sf. Spiridon Emergency Hospital; Iaşi-România

Non-alcoholic fatty liver disease (NAFLD) includes a range of disorders characterized by excess accumulation of triglycerides within the liver. While simple steatosis may be clinically stable, non-alcoholic steatohepatitis (NASH) can be progressive. Inflammation is believed to be the driving force behind NASH and the progression to fibrosis and subsequent cirrhosis. NAFLD is globally considered a significant health concern not only because of its incidence but also because of its economic impact. The fact that NAFLD is associated with cardiovascular disease is widely recognized, as well as the fact that NAFLD patient mortality rises when such an association is present. In particular, NAFLD is associated with coronary and carotid atherosclerosis, endothelial dysfunction and arterial rigidity, ventricles function, valves morphology, congestive heart failure, and arrhythmias (especially atrial fibrillation). Additionally, the hypercoagulability status in NAFLD patient may be suggested by the presence of inflammatory and coagulation markers. In order to differentiate between milder forms and the more severe ones that necessitate aggressive therapy, individualized risk scores may be used. This narrative review will analyze and interpret the papers published in PubMed in the last 16 years, in an attempt to expand our understanding of the NASH as a possible cardiovascular risk factor. (Anatol J Cardiol 2016; 16: 534-41)

Keywords: non-alcoholic fatty liver disease, cardiovascular disease, cardiovascular risk, risk score

Oana Sîrbu, Mariana Floria, Petru Dascalita, Victorita Şorodoc, Laurentiu Şorodoc. Non-alcoholic fatty liver disease–From the cardiologist perspective. Anatol J Cardiol. 2016; 16(7): 534-541

Corresponding Author: Mariana Floria, Romania
Manuscript Language: English


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