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Time-dependent Cervical Vagus Nerve Stimulation and Frequency-dependent Right Atrial Pacing Mediated Inducibility of Atrial Fibrillation [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-73558 | DOI: 10.14744/AnatolJCardiol.2018.73558  

Time-dependent Cervical Vagus Nerve Stimulation and Frequency-dependent Right Atrial Pacing Mediated Inducibility of Atrial Fibrillation

Mingliang Rao1, Jialu Hu2, Yan Zhang3, Feng Gao4, Feng Zhang5, Zhi Yang5, Xiaoya Zhang1, Yuemei Hou1
1Department of Cardiology, Affiliated Fengxian Hospital, Southern Medical University (Shanghai Fengxian Central Hospital), Shanghai, China.
2Department of Cardiology, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
3Department of Cardiology, First Hospital of Fuzhou City, Fuzhou city, Fujian Province, China.
4Department of Cardiology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen city, Fujian Province, China.
5Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Province, China.

Objective: We performed this study to explore the effects of right cervical vagus trunk simulation (RVTS) and/or right atrial pacing (RAP) in the induction of atrial fibrillation (AF).
Methods: Twenty-four healthy adult dogs were randomly divided into four groups: RAP groups included RAP500 (RAP with 500 beats per minute) and RAP1000 (RAP with 1000 beats per minute), and RVTS groups included RVTS and RAP500&RVTS. All dogs underwent 12-hour intermittent RAP and/or RVTS once every 2 hours. The AF induction rate, AF duration, atrial effective refractory period (ERP), and dispersion of ERP (dERP) were compared after every 2-hour period of RAP or/and RVTS.
Results: All groups had successful induction of AF. The RAP1000 group had the highest AF induction rate, and the longest AF durations. The RAP1000 group also had shortened ERP compared to the other groups, with the highest dERP. Compared to the RAP500 group, RAP500&RVTS had an increased capacity to induce AF as measured by the AF induction rates, AF durations, ERPs, and dERPs.
Conclusion: High tension in the vagus nerve and the intrinsic cardiac autonomic nervous system play an important role in inducing AF through different potential mechanisms. In the future, interventions to the vagus nerve and/or intrinsic cardiac autonomic nervous system could be a therapeutic option for AF.

Keywords: Vagus trunk, Right atrial pacing, Atrial fibrillation, Intrinsic cardiac autonomic nervous system




Corresponding Author: Yuemei Hou, China


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