Heart rate variability in normal-weight patients with polycystic ovary syndromeCelal Kilit1, Türkan Paşalı2
1Department of Cardiology, Faculty of Medicine, Dumlupınar University; Kütahya-Turkey
2Internal Medicine, Faculty of Medicine, Dumlupınar University; Kütahya-Turkey
Objective: Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors of cardiovascular disease. Obese women with PCOS show altered autonomic modulation. The results of studies investigating cardiac autonomic functions of normal-weight women with PCOS are conflicting. The aim of the study was to assess the reactivity of cardiac sympathovagal balance in normal-weight women with PCOS by heart rate variability analysis.Keywords: autonomic nervous system, heart rate variability, polycystic ovary syndrome
Methods: We examined the heart rate variability in 60 normal-weight women with PCOS and compared them with that in 60 age-matched healthy women having a similar metabolic profile. Time and frequency domain parameters of heart rate variability were analyzed based on 5-min-long continuous electrocardiography recordings for the following 3 periods: (1) during rest in supine position, (2) during controlled breathing, and (3) during isometric handgrip exercise.
Results: Time and frequency domain parameters of heart rate variability for the 3 periods assessed were similar in the two groups. Although modified FerrimanGallwey score and serum testosterone and luteinizing hormone levels were significantly higher in women with PCOS, homeostatic model assessment-insulin resistance (HOMA-IR) was not different the between the PCOS and control groups. There were no significant correlations between serum testosterone levels and heart rate variability parameters among the study population.
Conclusion: The findings of this study suggest that the reactivity of cardiac sympathovagal balance is not altered in normal-weight women with PCOS having a normal HOMA-IR. (Anatol J Cardiol 2017; 17: 000-00)
Corresponding Author: Celal Kilit, Türkiye