ISSN 2149-2263 | E-ISSN 2149-2271
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Vagus nerve stimulation: An evolving adjunctive treatment for cardiac disease [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(10): 804-810 | DOI: 10.14744/AnatolJCardiol.2016.7129

Vagus nerve stimulation: An evolving adjunctive treatment for cardiac disease

Barış Akdemir, David G. Benditt
Cardiovascular Division, Cardiac Arrhythmia and Syncope Center, University of Minnesota Medical School; Minneapolis, Minnesota-USA

The vagus nerve is a major component of the autonomic nervous system and plays a critical role in many body functions including for example, speech, swallowing, heart rate and respiratory control, gastric secretion, and intestinal motility. Vagus nerve stimulation (VNS) refers to any technique that stimulates the vagus nerve, with electrical stimulation being the most important. Implantable devices for VNS are approved therapy for refractory epilepsy and for treatment-resistant depression. In the case of heart disease applications, implantable VNS has been shown to be beneficial for treating heart failure in both preclinical and clinical studies. Adverse effects of implantable VNS therapy systems are generally associated with the implantation procedure or continuous on-off stimulation. The most serious implantation-associated adverse effect is infection. The effectiveness of non-invasive transcutaneous VNS for epilepsy, depression, primary headaches, heart failure, and other conditions remains under investigation. VNS merits further study for its potentially favorable effects on cardiovascular disease, especially heart failure. (Anatol J Cardiol 2016; 16: 804-10)

Keywords: atrial fibrillation, heart failure, vagus nerve stimulation, ventricular arrhythmia

Barış Akdemir, David G. Benditt. Vagus nerve stimulation: An evolving adjunctive treatment for cardiac disease. Anatol J Cardiol. 2016; 16(10): 804-810

Corresponding Author: Barış Akdemir, United States
Manuscript Language: English


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