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Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis [Anatol J Cardiol]
Anatol J Cardiol. 2018; 19(2): 86-93 | DOI: 10.14744/AnatolJCardiol.2017.8069  

Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis

Jin- Sen Lu1, Hong Wang1, Fei- Fei Yuan1, Le- Le Wu1, Bin Wang2, Dong- Qing Ye2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, P. R. China
2The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, Anhui, P. R. China

Objective: To evaluate the association between the tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms and common cardiovascular and cerebrovascular diseases.
Method: A literature-based search was operated through database including PubMed, EMBASE, Cochrane Library, CNKI and WanFang data. Crude odds ratios (ORs) and 95% confidence intervals (CI) were calculated to estimate the strength of the association between TNFSF4 polymorphisms (rs3850641 and rs17568) and the risk of coronary heart disease and stroke.
Results: 11 eligible studies were included in this meta-analysis. It was showed that G allele was not associated with CHD and stroke, compared with A allele (rs3850641: OR 1.02, 95%CI.: 0.89, 1.17; rs17568: OR 1.09, 95%CI.: 0.89, 1.33). Genotypic analysis demonstrated that there was no significantly association between the risk of CHD and stroke and rs3850641 (homozygous comparison (GG vs. AA): OR 1.05, 95%CI.: 0.74, 1.50; heterozygous comparison (GA vs. AA): OR 1.00, 95%CI.: 0.88, 1.13; recessive model (GG vs. GA + AA): OR 1.04, 95%CI.: 0.76, 1.43; dominant model (GG + GA vs. AA): OR 1.01, 95%CI.: 0.88, 1.17). Similarly, no susceptibility between CHD and stroke and rs17568 polymorphism was uncovered (GG vs. AA: OR 1.04, 95%CI.: 0.74, 1.46; GA vs. AA: OR 1.07, 95%CI.: 0.62, 1.83; GG + GA vs. AA: OR 1.13, 95%CI.: 0.82, 1.56; GG vs. GA + AA: OR 1.01, 95%CI.: 0.74-1.39).
Conclusions: The present study demonstrated that there is no significant relationship between TNFSF4 gene polymorphism and cerebrovascular and cardiovascular diseases.

Keywords: tumor necrosis factor superfamily member 4, coronary heart disease, stroke, polymorphism, meta-analysis


Jin- Sen Lu, Hong Wang, Fei- Fei Yuan, Le- Le Wu, Bin Wang, Dong- Qing Ye. Lack of association of tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3850641 and rs17568) with coronary heart disease and stroke: A systematic review and meta-analysis. Anatol J Cardiol. 2018; 19(2): 86-93

Corresponding Author: Bin Wang, China


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