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Effectiveness of computed tomography attenuation values in characterization of pericardial effusion [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-32815 | DOI: 10.14744/AnatolJCardiol.2016.7353  

Effectiveness of computed tomography attenuation values in characterization of pericardial effusion

Mehmet Serkan Çetin1, Elif Hande Özcan Çetin1, Mustafa Özdemir2, Serkan Topaloglu1, Dursun Aras1, Ahmet Temizhan1, Sinan Aydoğdu1
1Departments of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey
2Radiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey

Objective: The aim of this study was to evaluate the effectiveness of computed tomography (CT) attenuation values in the characterization of pericardial effusion.
Methods: This study consisted of 96 patients with pericardial effusion who underwent pericardiocentesis. For further diagnostic evaluation of pericardial effusion, all the patients were assessed by thorax CT. CT attenuation values were measured from at least 5 different areas of peri- cardial fluid by specifying the largest region of interest. The average of these measurements was computed and considered as the CT attenua- tion value of the patient. The patients were classified into two groups: patients with transudative pericardial effusion and those with exudative pericardial effusion.
Results: CT attenuation values were significantly higher in patients with exudative pericardial effusion than in those with transudative pericar- dial effusion [14.85±10.7 Hounsfield unit (HU) vs. 1.13±4.3 HU, p<0.001]. CT attenuation values had a close correlation with the pericardial fluid albumin (r=0.829), protein (r=0.752), and LDH (r=0.708) levels; WBC count (r=0.564); protein ratio (r=0.739); and LDH ratio (r=0.689) as well as the albumin gradient (r=–0.725). A cut-off value of 4.7 HU had 80% sensitivity and 87.7% specificity for the identification of exudative pericardial ef- fusion. In addition, a cut-off value of 6.5 HU had 71.4% sensitivity and 72.3% specificity for the prediction of cardiac tamponade.
Conclusion: In patients with pericardial effusion, CT attenuation values seem to be correlated with the characterization parameters of the fluid and may distinguish exudative pericardial effusion from transudative pericardial effusion. This parameter was also found to be a predictor of cardiac tamponade. CT attenuation values can be a useful tool in the clinical evaluation of patients with pericardial effusion. (Anatol J Cardiol 2017; 17: 000-00)

Keywords: computed tomography, attenuation, Hounsfield unit, pericardial effusion

Corresponding Author: Mehmet Serkan Çetin, Türkiye

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