ISSN 2149-2263 | E-ISSN 2149-2271
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Effects of glucose-insulin-potassium solution added to reperfusion treatment in acute myocardial infarction [Anatol J Cardiol]
Anatol J Cardiol. 2005; 5(2): 90-94

Effects of glucose-insulin-potassium solution added to reperfusion treatment in acute myocardial infarction

Baybars Türel1, Kani Gemici2, İbrahim Baran1, Dilek Yeşilbursa1, Sümeyye Güllülü3, Ali Aydınlar4, Akın Serdar1, Ali Rıza Kazazoğlu1, Ethem Kumbay5, Jale Cordan1
1Department of Cardiology, School of Medicine, Uludag University, Bursa, Turkey
2Gülhane Askeri Tıp Akademisi, Kalp Damar Cerrahisi Anabilim Dalı, Ankara Türkiye
3Uludağ Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Bursa, Türkiye
4Department of Cardiology, Faculty of Medicine, University of Uludağ, Bursa,Turkey
5Department of Cardiology Faculty of Medicine, Uludağ University, Bursa, Turkey

Objective: Reperfusion treatment modalities used in the routine treatment protocols of acute myocardial infarction (AMI) were found to be ineffective in establishing the nutritional cellular reperfusion in the microvascular environment even they succeed to open the infarct related artery. Glucose-insulin-potassium (GIK) solution, which is presumed to stimulate the glycolytic pathway, is experimentally proven to be the most efficacious substrate for the preservation of energy production and therefore the myocardial viability, in the setting of acute ischemia. Methods: We compared, 54 patients who suffered AMI and received GIK solution (300 g glucose+50 IU crystallized insulin+80 mEq potassium chloride in one liter solution) in addition to conventional treatment (GIK group) with 27 patients who were traditionally treated (control group) for in-hospital and early-term (1 month) cardiac morbidity. We also compared the two groups in terms of heart rate variability (HRV). Results: Eight patients in the control group, developed new-onset symptomatic congestive heart failure whereas only 5 patients in GIK group were found to have such a cardiac morbidity (p=0.01). Reduced HRV (<50 ms) was found in 3 patients of control group whereas no patient in GIK group had abnormal HRV (p=0.01). Conclusion: The GIK solution decreased the incidence of new-onset symptomatic congestive heart failure and low HRV after myocardial infarction. Larger multicenter trials need to resolve the questions on the efficiency of metabolic intervention with GIK solution in acute myocardial infarction.

Keywords: Glucose, insulin, potassium, myocardial infarction, heart rate variability.

Baybars Türel, Kani Gemici, İbrahim Baran, Dilek Yeşilbursa, Sümeyye Güllülü, Ali Aydınlar, Akın Serdar, Ali Rıza Kazazoğlu, Ethem Kumbay, Jale Cordan. Effects of glucose-insulin-potassium solution added to reperfusion treatment in acute myocardial infarction. Anatol J Cardiol. 2005; 5(2): 90-94
Manuscript Language: English


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