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Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-23682 | DOI: 10.14744/AnatolJCardiol.2018.23682  

Study of the association of 17 lipid-related gene polymorphisms with coronary heart disease

Nan Wu1, Guili Liu2, Yi Huang2, Qi Liao2, Liyuan Han2, Huadan Ye2, Shiwei Duan1, Xiaomin Chen1
1Key Laboratory of Ningbo First Hospital and Cardiovascular Center of Ningbo First Hospital, School of Medicine, Ningbo University; Ningbo, Zhejiang-China
2Medical Genetics Center, School of Medicine, Ningbo University; Ningbo, Zhejiang-China

Objective: Blood lipids are well-known risk factors for coronary heart disease (CHD). The aim of this study was to explore the association between 17 lipid-related gene polymorphisms and CHD.
Methods: The current study examined with 784 CHD cases and 739 non-CHD controls. Genotyping was performed on the MassARRAY iPLEX® assay platform.
Results: Our analyses revealed a significant association of APOE rs7259620 with CHD (genotype: χ2=6.353, df=2, p=0.042; allele: χ2=5.05, df=1, p=0.025; recessive model: χ2=5.57, df=1, p=0.018). A further gender-based subgroup analysis revealed significant associations of APOE rs7259620 and PPAP2B rs72664392 with CHD in males (genotype: χ2=8.379, df=2, p=0.015; allele: χ2=5.190, df=1, p=0.023; recessive model: χ2=19.3, df=1, p<0.0001) and females (genotype: χ2=9.878, df=2, p=0.007), respectively. Subsequent breakdown analysis by age showed that CETP rs4783961, MLXIPL rs35493868, and PON2 rs12704796 were significantly associated with CHD among individuals younger than 55 years of age (CETP rs4783961: χ2=8.966, df=1, p=0.011 by genotype; MLXIPL rs35493868: χ2=4.87, df=1, p=0.027 by allele; χ2=4.88, df=1, p=0.027 by dominant model; PON2 rs12704796: χ2=6.511, df=2, p=0.039 by genotype; χ2=6.210, df=1, p=0.013 by allele; χ2=5.03, df=1, p=0.025 by dominant model). Significant allelic association was observed between LEPR rs656451 and CHD among individuals older than 65 years of age (χ2=4.410, df=1, p=0.036).
Conclusion: Our study revealed significant associations of APOE, PPAP2B, CETP, MLXIPL, PON2, and LEPR gene polymorphisms with CHD among the Han Chinese.

Keywords: coronary heart disease, APOE, PPAP2B, CETP, MLXIPL, PON2, LEPR

Corresponding Author: Xiaomin Chen, China

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