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Treatment of saphenous vein graft lesions with paclitaxel- and sirolimuseluting stents: comparison of short- and long-term clinical outcomes [Anatol J Cardiol]
Anatol J Cardiol. 2008; 8(6): 431-436

Treatment of saphenous vein graft lesions with paclitaxel- and sirolimuseluting stents: comparison of short- and long-term clinical outcomes

Selçuk Görmez1, Refik Erdim1, Onur Erdoğmuş1, Murat Civan2, Alp Burak Çatakoğlu1, Murat Gülbaran2, Cemşid Demiroğlu1, Vedat Aytekin2
1Department of Cardiology, Florence Nightingale Hospital, İstanbul
2Department of Cardiology, Faculty of Medicine, İstanbul Bilim University, İstanbul, Turkey

Objective: The purpose of this study was to compare treatment of saphenous vein graft (SVG) lesions with paclitaxel-eluting (PES) and sirolimus-eluting stents (SES) in daily practice with regard to short- and long-term clinical outcomes.
Methods: Between August 2002 and September 2006, a total of 71 patients with SVG lesions who were implanted PES or SES with percutaneous coronary intervention in our center were evaluated retrospectively. Forty-six patients with PES (PES group) were compared to twenty-five patients treated with SES (SES group) in terms of in-hospital, 30-day, six-months and 1-year clinical outcomes. Statistical analyses were performed using Chi-Square statistics or Fisher’s exact and independent sample t test. Survival analysis was done using Kaplan-Meier method and log-rank test.
Results: Baseline clinical characteristics were similar in both groups except for a tendency toward a lower age in the SES group. No statistically significant difference was found between two groups by means of lesion and procedural characteristics. All clinical outcomes at 30-day, 6-month and 1-year after the interventions were similar in both groups. Early stent thrombosis was detected in one patient (2.2%) of PES group (p=0.65). Late stent thrombosis was not observed in both groups. The rate of major adverse cardiac events at 1-year was 8.7% in the PES group and 16% in the SES group (p=0.44).
Conclusion: Short- and long-term clinical outcomes of PES and SES in the treatment of SVG lesions are similar. The results of our study showed that both drug-eluting stents are effective and safe in real-world patient with diseased SVGs. (Anadolu Kardiyol Derg 2008; 8: 431-6)

Keywords: Drug-eluting stents, saphenous vein, angioplasty, outcomes, survival analysis


Selçuk Görmez, Refik Erdim, Onur Erdoğmuş, Murat Civan, Alp Burak Çatakoğlu, Murat Gülbaran, Cemşid Demiroğlu, Vedat Aytekin. Treatment of saphenous vein graft lesions with paclitaxel- and sirolimuseluting stents: comparison of short- and long-term clinical outcomes. Anatol J Cardiol. 2008; 8(6): 431-436

Corresponding Author: Vedat Aytekin, Türkiye


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