ISSN 2149-2263 | E-ISSN 2149-2271
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An important role for VCAM-1, but not for ICAM-1 in restenosis following coronary stent implantation [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(5): 405-409 | DOI: 10.5152/akd.2010.137

An important role for VCAM-1, but not for ICAM-1 in restenosis following coronary stent implantation

Serdar Bayata1, Erdinç Arıkan2, Murat Yeşil3, Nursen Postacı2, Mehmet Köseoğlu4, Abdülaziz Taş5
1Department of Cardiology, İzmir Atatürk Training and Research Hospital, İzmir, Turkey
2Clinic of Cardiology Atatürk Education and Research Hospital, İzmir-Turkey
3Department of Cardiology İzmir Atatürk Training and Research Hospital, İzmir, Turkey
4Department of Biochemistry Atatürk Teaching Hospital, İzmir, Turkey
5Department of Cardiology and, Atatürk Teaching Hospital, İzmir, Turkey

Objective: In this study, we evaluated the possibility that, levels of circulating adhesion molecules following direct stent implantation may be a marker of restenosis. Methods: This prospective, observational study investigated levels of circulating intercellular (ICAM-1), and vascular cell (VCAM-1) adhesion molecules in 15 patients with stable angina pectoris before and after coronary stent implantation for single vessel-single lesion disease in proximal left anterior descending artery. All patients received bare-metal stents. Patients underwent repeat coronary angiography for detection of restenosis at 6 month. Continuous data between patients with and without restenosis were compared using Mann-Whitney U test. Repeated measurements were compared using Wilcoxon T test. Categorical data were compared using Chi-square statistics. Results: Baseline ICAM-1 and VCAM-1 concentrations before percutaneous coronary intervention (PCI) were 4.89±2.28 and 46.35±22.96 ng/ml respectively. Levels of ICAM and VCAM increased nonsignificantly 24 hours after PCI (5.01±2.35 ng/ml and 52.57±19.40 ng/ml, respectively). Six patients (40%) developed restenosis within 6 months. Mean stent length, mean stent diameter, and mean dilatation pressure were comparable in patient groups with and without restenosis. Levels of plasma VCAM-1 measured before and after PCI did not change significantly in patients without restenosis. However, these levels increased significantly in the group of restenosis. At 6 months, patients who developed restenosis, had higher VCAM-1 levels, as compared to baseline values (from 45.1±21.0 to 57.2±14.3 ng/ml, p<0.05). Plasma levels of pre and post PCI ICAM-1 did not differ significantly between groups with and without restenosis. Conclusion: These results suggest a more dominant role for VCAM-1, but not for ICAM-1 in development of restenosis following coronary stent implantation.

Keywords: Restenosis, stenting, inflammation, vascular cell adhesion molecule-1, intercellular adhesion molecule-1

Serdar Bayata, Erdinç Arıkan, Murat Yeşil, Nursen Postacı, Mehmet Köseoğlu, Abdülaziz Taş. An important role for VCAM-1, but not for ICAM-1 in restenosis following coronary stent implantation. Anatol J Cardiol. 2010; 10(5): 405-409
Manuscript Language: English


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