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Potential of lipoproteins as biomarkers in acute myocardial infarction [Anatol J Cardiol]
Anatol J Cardiol. 2017; 18(1): 68-74 | DOI: 10.14744/AnatolJCardiol.2017.7403  

Potential of lipoproteins as biomarkers in acute myocardial infarction

Haseeb Ahmad Khan1, Aishah Ekhzaimy2, Isra Khan3, Meena Kishore Sakharkar4
1Department of Biochemistry, College of Science, King Saud University; Riyadh-Saudi Arabia
2Division of Endocrinology, Department of Medicine, King Khalid University Hospital; Riyadh-Saudi Arabia
3Department of Pathology, Rohilkhand Medical College and Hospital; Bareilly-India
4Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan; Saskatoon-Canada

Acute myocardial infarction (AMI), commonly known as heart attack, is a medical emergency that is potentially fatal if not promptly and properly managed. The early diagnosis of AMI is critically important for the timely institution of pharmacotherapy to prevent myocardial damage and preserve cardiac function. Ischemic insults during AMI cause myocardial tissue damage, releasing the cardiac muscle protein troponin T into the blood stream. Therefore, serum troponin T levels are used as a sensitive and specific indicator of myocardial injury for diagnosing AMI. However, there remains a requirement for developing technologies for more accurate biomarkers or signatures for AMI diagnosis or prognosis. Previous studies have implicated impaired lipid metabolism as a causative factor in AMI development. Lipoproteins are important constituents of lipid metabolism; their levels in the blood stream are a convenient biomarker tool for monitoring lipid metabolism. This review summarizes recent findings (data of studies from 2001 to 2016) regarding the biomarker potentials of various lipoproteins, including low-density lipoprotein, oxidized low-density lipoprotein, high-density lipoprotein, lipoprotein-a, and remnant lipoprotein, for the risk stratification of AMI.

Keywords: myocardial infarction, circulating lipoproteins, lipid metabolism, biomarkers


Haseeb Ahmad Khan, Aishah Ekhzaimy, Isra Khan, Meena Kishore Sakharkar. Potential of lipoproteins as biomarkers in acute myocardial infarction. Anatol J Cardiol. 2017; 18(1): 68-74

Corresponding Author: Haseeb Ahmad Khan, Saudi Arabia


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